Despite its small size, Harrisburg’s position as one of the hubs of the Pennsylvania Railroad made it a major economic player for the region, especially during the Industrial Revolution.
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One of the oldest cities in the nation, Philadelphia has a history as an important political and business hub; that said, it is still home to a number of established businesses – most notably Comcast – and startups alike.
Pittsburgh, aka the Steel City, is the is the second largest city in Pennsylvania and is an up and coming tech hub to watch in the U.S.