Nicknamed the “Heart of New York,” Syracuse has morphed from a major manufacturing city to a growing center for entrepreneurship, especially for students.

Initially settled as a fur trading hub, South Bend has been making strides to establish itself as an economic and entrepreneurial powerhouse. It’s considered to have the 2nd lowest cost of living in the U.S.

Though the St. Louis Arch shares the nickname, Omaha became known as the Gateway to the West due to its central location and status as a transportation hub. Today, the city is perhaps best known economically for being the headquarters of conglomerate Berkshire Hathaway.

Centrally-located city near a number of famous landmarks, Flagstaff is perhaps best known for its tourism economy. That said, the city is home to several manufacturing and medical technology companies in addition to major observatories.

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As part of the Rio Grande Tech Corridor, Albuquerque is home to a number of high-tech companies and is one of the 10 best for STEM workers in 2018.

Known as the Insurance Capital of the World, Hartford is a high-ranked city for economic measures and a growing city of entrepreneurship.

Milwaukee may be known as the home to multiple breweries, but Wisconsin’s largest city is establishing itself as a hub for Midwest entrepreneurship.

Nicknamed the “City of Trees” and perhaps best-known as home to potato farmers, Boise is a budding place for entrepreneurship and small business.

Tucson AZ, known as “Optics Valley” is growing into a substantial city for innovation and business, and is attracting many large manufacturing companies.

Long known as a transportation hub that earned both the city itself and the state as a whole the nickname “Crossroads of America,” Indianapolis’ strong economy makes it an attractive destination for entrepreneurs.