Buffalo, NY, named after the nearby Buffalo Creek, is New York’s second-largest city and perhaps the major connection point between the United States and Canada. Nicknamed “the City of Light” for its early adoption of electricity, that entrepreneurial and enterprising spirit carries on to this day.

One of the oldest cities in the nation, Philadelphia has a history as an important political and business hub; that said, it is still home to a number of established businesses – most notably Comcast – and startups alike.

The UpRamp Fiterator, backed by CableLabs, was designed to connect radical entrepreneurs to the most powerful network in the world. We look for established, later-stage startups that are changing how the world connects and guide them to finding product-market fit in the cable & broadband industry.

A shipping hub, Little Rock hosts the headquarters of some major companies such as Dillard’s. The city also has a burgeoning entrepreneurship scene…

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Thanks in part to its status as the home of the University of Michigan, Ann Arbor is ranked as the most-educated city in the world. Perhaps because of that high level of education, Ann Arbor is considered a good place for entrepreneurship.

Pittsburgh, aka the Steel City, is the is the second largest city in Pennsylvania and is an up and coming tech hub to watch in the U.S.

Queen City Fintech provides fintech startups access to world class mentors, capital, and leading financial services organizations; all in the heart of global banking hub Charlotte, NC.

Nicknamed the “Pittsburgh of the South,” Birmingham continues to be home to a number of well-known companies, especially those involved in steel or iron production such as McWane or O’Neal Steel.

SOMAVAC is a low-profile, wearable medical device that applies sustained vacuum to a closed surgical wound to remove fluid and minimize seroma.

Known primarily as a cultural destination, New Orleans’ status as a port city has long made it one of the region’s premier economic hubs. Home to some more-established businesses, the city is also the third-youngest entrepreneurship scene in the country.