Knoxville is a mid-sized city on the Tennessee River that is blossoming as an entrepreneurial hotspot in the Southeast United States.

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Photo Courtesy of Earl Neikirk/Neikirk Image

One of the best kept secrets of the southeast United States is a region made up of Bristol, TN / Bristol, VA, Johnson City, TN, and Kingsport, TN. Known as the Tri-Cities, this unique area possesses some of the best resources of a major city, without the problems and hassles of a major metropolitan area.

The Sunshine State’s third largest city, Tampa is gaining momentum as one of the best cities in the country for entrepreneurs.

Now more than ever, Austin’s entrepreneurial ecosystem is thriving. It is frequently ranked by several outlets as among the best cities in the country to start a business.

The coastal town of Wilmington has a long and proud history of strengthening the economy of North Carolina as a port city.

Originally founded as a hub for the major railroads, its location has attracted a number of manufacturing, financial and healthcare companies to Florence, SC.

Augusta is a small city on the Kennebec River with big potential for incoming entrepreneurs.

Juneau is the second-largest city by area in the USA with a strong tourism and fishing industry. Entrepreneurs are moving in and taking advantage of its beautiful scenery and budding opportunities.

The natural gas boom turned Jackson into a cultural and financial hub in the state of Mississippi and the Deep South.

With an extensive history in the food industry and business ventures, Salem is no stranger to the entrepreneurial mindset.